Cell Line Lysates
LifeSensors Parkin (Phosphorylated) 25µg
Encoded by the PARK2 gene, the E3 ligase Parkin is part of the multi-protein E3 complex that encodes substrate proteins for degradation in the Ubiquitin-Proteasome Pathway. The precise function of this protein is unknown; however, mutations in this gene are known to cause a familial form of Parkinson’s disease known as autosomal recessive juvenile Parkinson’s disease (AR-JP). Parkin is described to be necessary for mitophagy (autophagy of mitochondria)
ABclonal Technology CCR7 Rabbit pAb
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.
Abcam Human TMEM64 (TMM64) knockout A549 cell lysate.
Human TMEM64 (TMM64) knockout A549 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical StephacIdIn B 2.5mg
A fungal metabolite; converted to avrainvillamide in vitro; cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 µM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 µM, respectively); induces apoptosis in HepG2 and Huh7 cells at 4 µM
ABclonal Technology MUC1 Rabbit pAb
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.
Cayman Chemical Bak BH372-87humntrIf 10mg
A Bak-derived peptide; selectively binds to Bcl-xL over Bcl-2 (EC50s = 174 and 3,020 nM, respectively); induces apoptosis in LLC-PK1 cells
Sino Biological Human CD70 / CD27L / TNFSF7 Protein (Fc Tag), Endotoxin-Free 100µg
A DNA sequence encoding the extracellular domain of human CD70 (NP_001243.1) (Gln 39-Pro 193) was fused with the Fc region of human IgG1 at the N-terminus via a polypeptide linker.
Cayman Chemical UnIdentIfIed PF1163B 2.5mg
A depsipeptide antifungal; inhibits ERG synthesis (IC50 = 34 ng/ml); selectively inhibits growth of C. albicans (MIC = 32 UG/ml); acts synergistically with fluconazole to reduce growth of azole-resistant C. albicans (MIC = 0.0016 UG/ml); hydroxy form of PF-1163A
Cayman Chemical TPU-0037A 2.5mg
An antibiotic; inhibits the growth of Gram-positive bacteria, including MRSA, B. subtilis, and M. luteus (MICs = 1.56-12.5 μg/ml)
![Genetex Inc MTAP Monoclonal Antibody [MSVA-741R] HistoMAX™ (GTX04964) GeneTex - IHC-Optimized Antibody.](https://assets.fishersci.com/TFS-Assets/CCG/product-images/NC3668421.jpg-250.jpg)
Genetex Inc MTAP Monoclonal Antibody [MSVA-741R] HistoMAX™ (GTX04964) GeneTex - IHC-Optimized Antibody.
The MTAP antibody [MSVA-741R] HistoMAX™ (GTX04964) is a Rabbit Monoclonal antibody in the GeneTex HistoMAX portfolio. The antibody is extensively evaluated for IHC-P using formalin-fixed human normal tissues (more than 70 different sections) and cancer tissue arrays to guarantee specificity and best-in-class performance. Information regarding both manual and autostainer staining protocols are available.Figure Legend: IHC-P analysis of human ovarian stroma tissue using GTX04964 MTAP antibody [MSVA-741R] HistoMAX. Moderate predominantly cytoplasmic MTAP staining of ovarian stroma cells.
Sino Biological Recombinant Human CD9 Protein (Nanodisc, Full-length, His-GFP Tag), Fluorescent
A DNA sequence encoding the Human CD9 (P21926) (Met1-Val228) was expressed with a N-terminal polyhistidine tag followed by a GFP Tag. Nanodisc is a versatile tool for studying membrane proteins. Using styrene-maleic acid (SMA) copolymer, membrane proteins can be extracted directly from prokaryotic and eukaryotic expression systems in the absence of detergents to preserve the protein structure and function better. Compared to membrane scaffold proteins (MSPs) nanodiscs, SMA nanodiscs also have the advantage of preserving proteins' nature by maintaining native lipids surrounded without introducing any heterologous proteins, which allows studies of protein structure and functions in a native-like environment.
ABclonal Technology L3MBTL2 Rabbit pAb
Enables methylated histone binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to act upstream of or within several processes, including ectoderm development, regulation of histone modification, and stem cell proliferation. Located in nucleus.
ABclonal Technology ADK Rabbit pAb
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene.
Abcam Human ZC3HAV1 (Zinc finger antiviral protein) knockout A549 cell lysate.
Human ZC3HAV1 (Zinc finger antiviral protein) knockout A549 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology SNAPIN Rabbit pAb
The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants.